We looked at the link between synovial transcriptomic profiles and disease activity (DAS28CRP, CDAI, SDAI) in a series of 65 RA synovial biopsies (44) and found a strong correlation between all 3 measures and transcripts associated with an overwhelming lymphoid, but also, to a lesser extent, myeloid (TNFα-dependent) signature. The gene discussed is TNF; the disease is rheumatoid arthritis.