Stimulating autophagy with mTOR inhibitors like rapamycin or its analogs had beneficial effects in fly and mouse models of Huntington’s disease, Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal dementia (FTD), spinocerebellar ataxia type 3 (SCA3) and prion disease (Ravikumar et al., 2004; Berger et al., 2006; Sarkar et al., 2008; Menzies et al., 2010; Spilman et al., 2010; Cortes et al., 2012; Wang et al., 2012; Ozcelik et al., 2013; Jiang et al., 2014). The gene discussed is MTOR; the disease is Alzheimer disease.