AATD mice (Hidvegi et al., 2010), NAFLD and AFLD mice (Lin et al., 2013), FSD patients (Puls et al., 2013), AATD patient iPSC-derived hepatic cells (Choi et al., 2013), NPC1 patient iPSC-derived hepatic cells (Maetzel et al., 2014). Here, NPC1 is linked to metabolic dysfunction-associated steatotic liver disease.