NPC1 and Alzheimer disease: Remarkably, trehalose had beneficial effects in mouse models of AD, PD, HD, FTD, SCA17, ALS, as well as cellular and iPSC-derived neuronal models of prion and NPC1 disease, respectively (Tanaka et al., 2004; Aguib et al., 2009; Rodriguez-Navarro et al., 2010; Schaeffer et al., 2012; Castillo et al., 2013; Du et al., 2013; Zhang et al., 2014; Chen et al., 2015; Tanji et al., 2015).