Moreover, Nos2 expression and NO production kill parasites and result in resistance to infection (Ghalib et al., 1995; Wei et al., 1995; Vieira et al., 1996; Wilhelm et al., 2001; Yang et al., 2007; Ben-Othman et al., 2009; Srivastava et al., 2012; Muxel et al., 2017b, 2018a,b). Here, NOS2 is linked to infection.