Moreover, miR-30e alters cell proliferation, colony formation and invasiveness in cancer cells, interfering with NF-κB/IκBα negative feedback and apoptosis (Jiang et al., 2012; Hershkovitz-Rokah et al., 2015; Zhuang et al., 2017), suggesting a putative role of NF-κB activation during miR-30e-5p inhibition and increased levels of Nos2. This evidence concerns the gene NOS2 and cancer.