Gao et al. demonstrated the immunomodulating effects of AHCC in a study that showed enhanced antigen (Ag) activation of CD4 (+) and CD8 (+) T cells, and the increased frequency of tumor Ag-specific IFN-gamma producing CD8 (+) T cells as well as increases in cell numbers of NK cells and gamma delta T cells (10). The gene discussed is CD8A; the disease is neoplasm.