1996). Consistently, liver-specific knockout IR mice also show hyperglycemia, hyperlipidemia, hyperinsulinemia and obesity (Michael et al. 2000). Furthermore, Won-Mo Yang et al have reported that mir-195 which was induced by saturated fatty acid could impair insulin signaling and glycogen metabolism in HepG2 cells though targeting IR (Yang et al. 2014). This evidence concerns the gene INS and Hyperglycemia.