INS and type 2 diabetes mellitus: 2013). Type 2 diabetes is characterized by hyperglycemia and decreased response of peripheral tissues to insulin (Kahn et al. 2006; Petersen and Shulman 2006). Hepatic insulin resistance is one of the most important causes for the development of type 2 diabetes. In the state of insulin resistance, the liver's response to insulin is reduced, while gluconeogenesis is increased and glycogen synthesis is reduced simultaneously, eventually leading to hyperglycemia in the body (Samuel and Shulman 2012).