2000). Despite intensive studies on hydrangenol, researches on the effect of hydrangenol against cancers are very limited. Previously, we have reported that hydrangenol has potent anticancer activity against bladder cancer, which is the fourth most common cancer in the United States of America (Shin et al. 2018). As a follow-up study, we investigated the potential antiangiogenic activity of hydrangenol using both in vitro HUVECs and ex vivo aortic ring systems stimulated by VEGF as models of angiogenesis. The gene discussed is VEGFA; the disease is urinary bladder carcinoma.