One of the mechanisms acquired by cancer cells in order to counteract potential toxic effects conferred by elevated ROS levels appears to be concomitant upregulation of antioxidants [17], as suggested by the observation of increased peroxiredoxin-3 and thioredoxin peroxidase levels in H-ras transformed cells as compared to nontumorigenic counterparts [44]. Here, PRDX3 is linked to cancer.