HSPA5 and Parkinson disease: To elucidate the role of echinacoside in the regulation of GRP78/BiP in an experimental model of PD, Zhang and colleagues revealed that echinacoside attenuated the upregulation of GRP78/BiP in 6-OHDA-treated PC12 cells and Sprague–Dawley rats injected with 6-OHDA, thus highlighting the neurotherapeutic potential of echinacoside in experimental models of PD [132].