The different results between injecting a relatively large number of exogenous BMDM in the tumor or letting the tumor recruit endogenous macrophages as it expanded could suggest, among other interpretations, that although NFAT5 can favor the polarization of pro-inflammatory macrophages under appropriate stimulation, this influence cold be neutralized in a sustained pro-M2 microenvironment imposed by the tumor. The gene discussed is NFAT5; the disease is neoplasm.