NFAT5 and neoplasm: Adoptive transfer experiments of BMDM in mice harboring ID8-Luc ovarian tumors in the peritoneal cavity or subcutaneous Lewis lung carcinoma (LLC) tumors showed that NFAT5-deficient macrophages were less effective than wild-type ones at delaying tumor growth, an observation consistent with being less capable of maintaining a pro-inflammatory or M1 phenotype (18).