Interestingly, when studying these two cDCs subsets present in the tumor-draining lymph node, we detected a more activated phenotype only on CD103+ cDC1 and not on CD11b+ cDC2, indicating that either activated CD103+ cDC1 traffic to the lymph node or poly A:U reaches the lymph node activating the only TLR3-expressing population there, i.e., CD103+ cDC1. The gene discussed is MPPE1; the disease is neoplasm.