Our T cell transfer data showing no difference in arthritis (Figure 5D) and SFB level (Figure 5F) between P2RX7-deficient and WT groups indicate that lower SFB levels in whole-mouse P2RX7 deficiency (Figure 5C) was not solely responsible for the lack of arthritis difference between WT and P2rx7−/− mice in SFB(+) condition (Figures 5A,D) when compared to SFB(–) condition (Figures 1A, 3B). Here, P2RX7 is linked to arthritic joint disease.