Further studies are needed in patients with ICAS-LVO to determine the first-line device and technique for thrombectomy (stentriever, ADAPT, or Solumbra), pharmacological adjunct (intravenous tPA or intra-arterial antithrombotics), and cessation time for procedures in cases of repetitive reocclusion. This evidence concerns the gene PLAT and familial isolated congenital asplenia.