SERPINE1 and hepatocellular carcinoma: In a mouse model of sporadic tumorigenesis, instead, the activation of the oncogene MET brought to the generation of spontaneous multifocal hepatocellular carcinoma (HCC), together with a lethal thrombohemorrhagic syndrome as a consequence of cyclooxygenase-2 (COX-2) and PAI-1 up-regulation, since some clinical symptoms got milder when treatment with their inhibitors was performed (49, 55).