TF release, and the following thrombin activation, not only trigger the hemostatic process but also several pathogenic events crucial for cancer progression, such as cell survival and invasion, as well as angiogenesis processes, through the activation of the protease-activated receptor (PARs) proteins, a group of membrane receptor proteins (PAR 1–4), expressed by tumor cells and vascular cells, that mediate cell activation via G protein pathways (29–32). The gene discussed is TF; the disease is cancer.