A particular study, on the other side, elegantly demonstrated that the overexpression of TF and the procoagulant activity of GBM cells, after the inactivation of PTEN, are triggered only under hypoxic conditions or together with the EGFRvIII expression, demonstrating how the activation of specific oncogenic pathways, rather than individual mutations, may drive tumor cells to express a particular procoagulant phenotype (48, 53, 54). This evidence concerns the gene TF and neoplasm.