These findings suggested that specific cancer cell phenotypes may affect the coagulation system, that the deregulation of haemostasis in tumors microenvironment is not “unspecific” and that the activation of oncogenes (such as EGFR, MET, or RAS) and the inactivation of tumor suppressor genes (such as PTEN or p53) directly affect the expression of hemostasis-controlling genes (50, 51). The gene discussed is EGFR; the disease is cancer.