SERPINE1 and neoplasm: Tumor cells, at the same time, can synthesize all of the components of the fibrinolytic system, such as urokinase-type plasminogen activator (uPA) and its receptor (uPAR), tissue-type plasminogen activator (tPA) and plasminogen activator inhibitors 1 (PAI-1) and 2 (PAI-2).