TF and neoplasm: In particular, the TF/factor VII (FVII) complex proteolytically activates PAR-2 and the formed TF-FVII-PAR-2 complex guides the expression of tumor metastasis by modulating genes that regulate cell survival and migration, inducing, at the same time, the release of pro-angiogenic factors, such as CXCL1, VEGF, and IL-8.