Likewise, the interaction of thrombin with PAR-1, PAR-3, and PAR-4 triggers several signaling pathways in cancer cells ending with the overexpression of many angiogenesis-related genes, like bFGF, TF, VEGF, VEGF receptor (VEGFR), and metalloproteinase 2(MMP-2) (Figure 1) (33, 34). Here, VEGFA is linked to cancer.