GH1 and major depressive disorder: Indeed, some studies suggest that depression may be linked to endocrine alterations: nocturnal cortisol secretions (Birmaher et al., 1996), nocturnal growth hormone secretion (Ryan et al., 1994), thyroid stimulating hormone secretion (Puig-Antich, 1987), melatonin and prolactin secretions (Waterman et al., 1994), high cortisol levels (Herane-Vives et al., 2018), or decreased growth hormone production (Dahl et al., 2000).