GCK and pancreatic insulinoma: Bedoya and coworkers had discovered in 1986 (Bedoya et al., 1986a,b) that GCK expression was differentially regulated in liver and endocrine pancreas when characterizing the effects of a transplantable insulinoma on GCK expression in liver and islets of Langerhans in NEDH rats (New England Diakonis Hospital rats).