PLK1 and cancer: Of the more than 9,000 possible interactions tested herein, 104 (ca. 1.0%) were significant (Z-score of >3), while 4 of the top 9, including interactions between CTX and cortactin (CTTN; Z-score 32.27), polo-like kinase 1 (PLK1; Z-score 11.20), homeobox protein HOXB6 (Z-score 10.47), and XTP3-transactivated protein A (XTP3TPA; Z-score 6.21825), are relevant to the present investigation as these proteins have been shown to be involved in cancer.