Also, analysis of human NASH samples and in human studies, intrahepatic T cells show in general higher expression levels of the receptors PD1 and 2B4, independent of the underlying liver disease (Golden-Mason et al., 2007; Radziewicz et al., 2007; Kroy et al., 2014a; Figure 6). Here, PDCD1 is linked to metabolic dysfunction-associated steatohepatitis.