Although further preclinical studies and controlled clinical studies are necessary to assess the efficacy and the safety profile of TM38837, these findings correspond well with the alternative approach in the treatment of obesity, which could be represented by the use of peripheral or neutral CB1 antagonists, lacking many of the adverse events associated with CB1 inverse agonist (Shrestha et al., 2018; Tam et al., 2018). This evidence concerns the gene CNR1 and obesity due to melanocortin 4 receptor deficiency.