HAPLN2 and Alzheimer disease: For example, Martins-de-Souza et al. (2009) showed that the expression levels of Hapln2 in the anterior temporal lobe are lower in patients with schizophrenia than those of the control subjects, and Minjarez et al. (2013) suggested that Hapln2 was probably in the neurofibrillary tangles (NFTs) from AD brain.