SNCA and Parkinson disease: Alpha-synuclein (αS) has long been a protein of great interest because of its pathological aggregation in neuronal plaque and Lewy bodies, which are associated with Parkinson’s Disease and Lewy Body Dementia, respectively (Hardy and Gwinn-Hardy, 1998; Shimohama et al., 1998; Lee and Trojanowski, 2006; Spillantini et al., 2010).