TF and Skeletal muscle atrophy: Studies have shown increased serum ferritin levels, transferrin saturation coefficient, and decreased transferrin in ALS patients, which could reflect a general increase in iron stores or be a consequence of on-going muscle degeneration (Goodall et al., 2008; Qureshi et al., 2008; Nadjar et al., 2012; Hu et al., 2016).