OPTN and amyotrophic lateral sclerosis: Thanks to recent advances in genetics, we now know that ALS is associated with mutations in at least 20 genes, coding for proteins related to cell functions as diverse as RNA metabolism (TARDBP, FUS/TLS, Senataxin, Ataxin2, HNRNPA2/B1, ELP3, HNRNPA1), vesicle trafficking (Alsin, FIG4, OPTN, VABP, CHMP2B), and proteasomal function (UBQLN2, VCP) (White and Sreedharan, 2016).