We found that, in the tumor tissue obtained from mice, lycopene significantly upregulated the mRNA levels of IFNβ, IFNγ, IRF1, IRF7, CXCL9 and CXCL10, whereas no effect was observed on IRF3 and IRF8 (Fig. 4a–d). This evidence concerns the gene CXCL9 and neoplasm.