Thus, based on these findings, we postulated that Cx43 channels regulate ROS generation and distribution between intestinal epithelial cells, thus regulating the activity of the JNK1/Sirt1/FoxO3a signaling pathway, resulting in the expression of proapoptotic Bim and Puma and sepsis-induced intestinal injury aggravation. This evidence concerns the gene GJA1 and Sepsis.