Opioid-related nociceptin receptor 1 (OPRL1), the target that accounts for the analgesic activity of JTC801, is dispensable for alkaliptosis.238 Of note, JTC801 has also been reported to induce apoptosis in human osteosarcoma cells,239 suggesting that the type of RCD triggered by JTC801 depends on the cellular context. This evidence concerns the gene OPRL1 and osteosarcoma.