Different cathepsins are responsible for the initiation and execution of LCD, depending on the context of lysosomal membrane permeabilization.219 The transcription factors signal transducer and activator of transcription 3 (STAT3)220 and TP53221 may favor LCD induction through the selective upregulation of cathepsins (e.g., CTSB, cathepsin L [CTSL] and cathepsin D [CTSD]) expression. This evidence concerns the gene CTSD and lattice corneal dystrophy type I.