Next, we monitored the effect of the co-treatment of DCA with 17-AAG on macroautophagy by evaluating the autophagy flux in cells with different p53 status of (Fig. 4b).We did not observe any significant change in autophagy in OCI-AML-3 (wt p53) and HL-60 cells (p53 null) after DCA and/or 17-AAG treatments. Here, TP53 is linked to acute myeloid leukemia.