Our current study suggests that PX-12 also acts as an entry inhibitor although further studies need to be conducted to clarify whether PX-12 mediate its effect with a similar target also in primary cells.Trx1 and TrxR1 are often highly expressed in tumor cells and it is possible that PX-12 only blocks some of the Trx1 system dependent processes in the TZM-bl cells and thereby displays lower toxicity than in primary cells at the same given concentration. Here, TXNRD1 is linked to neoplasm.