Notably, in 2013, Zhang and collaborators have demonstrated that, in multiple myeloma cells, a reduction of 50% in DEPTOR mRNA lead to a similar decrease at the protein level and to changes in the profile of downstream elements of mTOR pathway (as in the phosphorylation of 4EBP1 and Akt), as well as a reduction of cell proliferation31,32. The gene discussed is AKT1; the disease is plasma cell myeloma.