A still higher levels of GIP in patients of acromegaly with hyperglycaemia as compared to those with euglycemia could possibly have resulted from hyperglycaemia-induced desensitization of GIP receptors on β-cells (GIP resistance), as also seen in patients with T2DM35.This was further substantiated by significantly lower AUC C-peptide/GIP ratio in patients of acromegaly with diabetes as compared to those with euglycaemia. The gene discussed is GIP; the disease is diabetes mellitus.