As shown in Table 1, high expression of GHET1 was associated with advanced clinical stage (I–IIA vs IIB–IV, P<0.001), lymph node metastasis (absent vs present, P<0.001), distant metastasis (absent vs present vs, P=0.010) and poor histological grade (well vs moderately/poorly, P=0.003). This evidence concerns the gene GHET1 and metastatic malignant neoplasm in the lymph nodes.