Up to now, at least 20casuative genes of OI have been identified, including COL1A1, COL1A2,IFITM5, CRTAP, LEPRE1, FKBP10, PLOD2, PPIB, SERPINF1, SERPINH1, SP7, WNT1, BMP1,TMEM38B, PLS3, CREB3L1, SEC24D, SPARC, P4HB, andMBTPS2, which are involved in encoding or post-translationalmodification process of type I collagen or regulating osteoblasts function [4–9]. This evidence concerns the gene COL1A2 and osteogenesis imperfecta.