When human nephrectomy tissue samples from patients with or without diabetic nephropathy (n = 6 for each group) were examined by immunofluorescence or by immunoblotting, we consistently found that increased levels of KDM6A and KLF10, accompanied by reduced levels of nephrin and WT‐1, were significantly detected in kidney tissues of diabetic nephropathy patients as compared to control subjects (Fig 7A and B). Here, KDM6A is linked to diabetic kidney disease.