In this study, we report a new deleterious pathway driven by a positive feedback loop involving KDM6A and KLF10, a SP/KLF member originally identified as a TGF‐β‐inducible early gene product (Subramaniam et al, 1995), in podocytes under diabetic conditions, and suggest that inhibition of the regulatory pathway may help prevent progression of diabetic nephropathy. This evidence concerns the gene KDM6A and diabetic kidney disease.