Although several KLF members including KLF2, KLF4, KLF6, and KLF15 in glomerular endothelial cells or podocytes have been linked to kidney diseases, all these reported KLF members serve as renal protectors (Mallipattu et al, 2012, 2015, 2017; Hayashi et al, 2014, 2015; Zhong et al, 2015, 2016). This evidence concerns the gene KLF15 and kidney disorder.