First, variants in TAF1, TAF2, TAF8 and TAF13 have all been linked to intellectual disability and microcephaly (O'Rawe et al., 2015; Hellman-Aharony et al., 2013; Tawamie et al., 2017; El-Saafin et al., 2018). Here, TAF1 is linked to Intellectual disability.