Neuropathy of any grade was more frequent in participants given RB-CHOP than among those given R-CHOP (252 (56·8%) RB-CHOP vs 186 (41·6%) given R-CHOP; p<0·0001; appendix pp 8–11) but there was no significant difference in the event rate of neuropathy of grade 3 or higher (17 (3·8%) RB-CHOP vs eight (1·8%) R-CHOP; p=0·070). Here, DDIT3 is linked to neuropathy.