The enrichment folds (s.e.) for SNPs associated with childhood BMI-adult trait vs. SNPs associated with adult trait only vs. SNPs associated with childhood BMI only were as follows: 1.60 (0.13) vs. 1.38 (0.12) vs. 1.29 (0.06) for coronary artery disease; 2.52 (0.22) vs. 0.91 (0.23) vs. 1.22 (0.07) for hemoglobin A1C; 7.31 (1.79) vs. 1.11 (0.39) vs. 1.33 (0.05) for insulin secretion; and 1.68 (0.14) vs. 1.11 (0.19) vs. 1.27 (0.06) for myocardial infarction (Fig. 1, Additional file 1: File S2). This evidence concerns the gene INS and coronary artery disorder.