These included 86 cytosines in naïve CD4+ T cells [45], 1082 CpGs in T cells, 264 CpGs in B cells, 168 CpGs in monocytes [15], 293 sites in neutrophils [46], 26,298 CpGs in PBMCs [47], and 44 cytosines differentially methylated in white blood cells from SLE patients [48]. This evidence concerns the gene CD4 and systemic lupus erythematosus.