Because accelerating plaque angiogenesis can lead to the expansion and rupture of a plaque, the potential risk of an angiogenesis-borne disease exists and includes tumour formation and metastasis, the aggravation of diabetic retinopathy, etc. Thus, we will investigate the combination of BMSCs and TSP4 in angiogenesis and homeostasis in future research. The gene discussed is THBS4; the disease is diabetic retinopathy.