The finding that many genes with functions in fatty acid (FA) metabolism, such as multiple FA elongases (Additional file 3: Table S2), fatty acid 2-hydroxylase (FA2H), and arachidonate 12-lipoxygenase (ALOX12B, which produces an eicosanoid signaling molecule that stimulates epidermal lipid envelope synthesis; see Fig. 6c) are downregulated in sarcoma vs. normal skin (see also Fig. 1d, “long-chain fatty acid metabolism”) is interesting. This evidence concerns the gene ALOX12B and sarcoma.