The finding of enrichment of ECM-related genes among the 53 genes that are upregulated in sarcoma is consistent with the abundant ECM typically seen in histopathological analysis of FISS tumors [3] and the upregulation of both ECM structural constituents (COL6A3, FBN2, LAMA4), as well as degradative enzymes (MMP13, ADAM28) is suggestive of ECM remodeling. This evidence concerns the gene FBN2 and sarcoma.