The finding of enrichment of ECM-related genes among the 53 genes that are upregulated in sarcoma is consistent with the abundant ECM typically seen in histopathological analysis of FISS tumors [3] and the upregulation of both ECM structural constituents (COL6A3, FBN2, LAMA4), as well as degradative enzymes (MMP13, ADAM28) is suggestive of ECM remodeling. The gene discussed is MMP13; the disease is sarcoma.