FN1 and renal carcinoma: Given that BARX1 transcript abundance is nearly forty-fold higher in FISS than in skin, and given our interest in the FISS-upregulated gene FN1 (a five-fold FISS-upregulated gene that encodes fibronectin-1, an ECM protein that has an important role in cell adhesion, growth, migration, and differentiation and whose expression is associated with more advanced disease in renal cancer [88]), we selected BARX1 and FN1 to assay at the protein level.