Interleukin-12 is produced by activated phagocytic cells such as macrophages, dendritic cells, and neutrophils; it influences both innate and adaptive arms of the immune system, including augmenting cytotoxic CD8+ T-cell activation [66], reprogramming T helper 17 (TH17) cells into a TH1 phenotype, and reprogramming tumor-associated antigen-presenting cells to prime cytotoxic T-cells for antitumor activity [66, 67]. Here, CD8A is linked to neoplasm.