Among the genes that are upregulated in sarcoma in all three species, several genes stand out: FAP (fibroblast activation protein α) is known to be expressed in soft tissue sarcomas and is involved in control of fibroblast growth [59], WT1 (Wilms tumor suppressor) is expressed in over half of soft tissue sarcomas and has prognostic significance [60], and PRAME (preferentially expressed antigen in melanoma) promotes cell growth, is expressed in tumors including soft tissue sarcomas, and has been proposed as a potential immunotherapy target for sarcoma [61]. The gene discussed is PRAME; the disease is melanoma.