While stromal derived nidogen-2 has previously been shown to repress the number of metastases in a melanoma model [52] and its expression has also been shown to inhibit metastasis in nasopharyngeal and oesophageal carcinoma [53], equal expression of nidogen-2 in confluent and subconfluent HUVEC cells indicates that nidogen-2 does not play any role in the endothelial control of SK-BR-3 breast cancer cell migration. The gene discussed is NID2; the disease is breast cancer.