As shown in Fig. 1 and Table 3, a significant allelic association was recorded under a random-effect allelic model, with OR = 0.85 (95% CI 0.76–0.94, P = 0.003), indicating that the G-allele is a protective allele of KIF1B for HCC compared to A-allele. This evidence concerns the gene KIF1B and hepatocellular carcinoma.