Interestingly, Oguchi disease patients, and congenital stationary night blindness patients in general, frequently experience a strong photophobia.50 Collectively, our results together with recent clinical findings27,28,45, –47 suggest that the stationary nature of diseases caused by GNAT1, SAG (Arr1), and GRK1 mutations should be taken with caution. This evidence concerns the gene ARRB1 and Oguchi disease.