SPP1 and familial hyperaldosteronism: In view of the impact of hypoxia on the expression of selected genes in our equine in vitro FH model, we observed that upregulation of osteogenic (RUNX2, SPP1), hypoxia-induced (PGK1, LDHA, PFKFB3, SLC2A1) and angiogenic (VEGFA, MIF) genes/factors essential for fracture healing after incubation for 48 h takes place at a higher extent under hypoxic than under normoxic conditions (Fig 5).