The aims of this study were to assess the prognostic value of a single determination of cortisol, DHEA, DHEAS and their ratios on Intensive Care Unit (ICU) admission in severe sepsis and septic shock patients, as well as to compare this with the prognostic value of a single determination of classical biomarkers, such as arterial lactate or C-reactive protein (CRP) on ICU admission, and to evaluate whether the addition of the same to SOFA could improve the prognostic accuracy of this severity score. This evidence concerns the gene CRP and Sepsis.