In ischemic cardiovascular diseases, such as CAD, pathology is associated with endothelial damage and inflammation, downregulation of the EPC cell population and function, and impaired angiogenesis.[16] It implies that PIK3C2A may play a role in the development and progression of cardiovascular diseases (CADs) by affecting platelet function and impaired angiogenesis. Here, PIK3C2A is linked to coronary artery disorder.