By the end of 2015, a total of 392 million people suffer from T2D worldwide.[1] T2D is a long-term metabolic disorder which is characterized by the relative lack of insulin, insulin resistance, and high blood glucose.[2] It has been well known that T2D is a major risk factor for premature mortality and adverse complications such as blindness, stroke, heart attack, amputation, and kidney failure.[3]. The gene discussed is INS; the disease is type 2 diabetes mellitus.