Importantly, the palmitoylation of amyloid precursor protein (APP) and huntingtin are implicated in Alzheimer’s disease and Huntington’s disease pathogenesis, respectively (Huang et al., 2004; Smith et al., 2005; Zheng and Koo, 2006; Bhattacharyya et al., 2013). Here, APP is linked to early-onset autosomal dominant Alzheimer disease.