B6 mice encoding a functional murine Mx1 gene locus (Mx1) are known to be highly resistant to infections with influenza viruses of both human and avian origin such as KAN-1, A/R65 (H5N1), A/SH/1 (H7N9) and A/SC35M (H7N7) (Figure 3(c)) [12]. The gene discussed is MX1; the disease is infection.