Curcumin in combination with (−)‐epigallocatechin‐3‐gallate markedly reduces tumor growth and microenvironment‐induced angiogenesis via modulation of the JAK/STAT3/IL‐8 pathway in colorectal carcinoma.32 Treatment with resveratrol can downregulate angiogenesis via decreased expression of VEGF in the tumor microenvironment.54 Berberine has been shown to reduce tumor‐induced angiogenesis both in vitro and in vivo.69 Cancer‐associated fibroblasts, a major component of the tumor microenvironment, stimulate tumor progression through cross‐talk. This evidence concerns the gene STAT3 and neoplasm.