CD4 and neoplasm: In a mouse renal tumor model, resveratrol was shown to enhance the accumulation of activated CD8(+) T cells in the tumor microenvironment and increase the expression of Fas ligand so as to exert cytotoxicity.54 The regulatory subpopulation of cells (CD4(+)CD25(+)FoxP3(+)Treg cells) is among the most potent and well‐studied tumor‐induced immunosuppressive phenotype that exists within the tumor microenvironment.