Cancer immunotherapy was ranked as 2013’s Breakthrough of the Year by Science. 166 Recently, regulation of the immune system to eliminate cancer cells has succeeded in clinics through the use of immune checkpoint therapy that utilizes blocking antibodies to cytotoxic T lymphocyte antigen‐4 (CTLA‐4) and programmed death‐1 (PD‐1), and via chimeric antigen receptor (CAR) T cells.167 TCM can also offer a potential immunomodulatory regimen for the treatment of a number of diseases, including cancer. The gene discussed is CTLA4; the disease is cancer.