Researches showed that SNHG15 is overexpressed in gastric cancer (GC), nonsmall cell lung cancer (NSCLC) and breast cancer, and it could promote cell proliferation in these cancers.19, 20, 21, 22, 23, 24 In this study, we proved that SNHG15 is up‐regulated in CRC tissues than the matched noncancerous tissues (NCTs). This evidence concerns the gene SNHG15 and cancer.