A large number of studies have reported that lncRNA plays an extremely important role in the occurrence and development of human cancers, including CRC.10 For example, HOTAIR promoted cell proliferation and chemoresistance of CRC via miR‐203a‐3p‐mediated Wnt/ß‐Catenin signaling pathway.11 LncRNA‐H19 accelerated cell proliferation and metastasis in CRC and melanoma cells.12, 13, 14 Our previous studies demonstrated that UCA1, LINC00152, FEZF1‐AS1, and SNHG6 function as oncogenes to promote cell proliferation, metastasis, and chemoresistance of CRC cells.15, 16, 17, 18. Here, HOTAIR is linked to colorectal carcinoma.