SNHG15 was initially found to be overexpressed in GC and could promote cell proliferation and invasion of GC.19 SNHG15 was subsequently confirmed to be up‐regulated and worked as an oncogene in hepatocellular carcinoma, osteosarcoma, pancreatic cancer, and breast cancer.21, 23, 25, 26 We also found that SNHG15 was obviously up‐regulated in CRC tissues compared with paired NCTs and predicted poor prognosis of CRC patients. This evidence concerns the gene SNHG15 and osteosarcoma.