Previous studies have demonstrated that miR‐338‐3p could function as a tumor suppressor in GC, NSCLC and CRC.31, 32, 33 We also confirmed the anti‐carcinogenic effect of miR‐338‐3p in CRC in this study, and the function of miR‐338‐3p is inhibited after sponged by SNHG15. This evidence concerns the gene SNHG15 and colorectal carcinoma.