CASP3 and pancreatic neoplasm: Moreover, FGF/FGFR‐1 exerted its function via regulation of receptor tyrosine phosphorylation and MAPK activation in pancreatic cancer.83 Overexpression of FGFR‐1α increased cell death via activation of caspase 3 and inhibition of Bcl‐xL (B‐cell lymphoma‐extra large)/BAX in pancreatic cancer cells.