FGFR4 stimulation led to increased cell adhesion to laminin and fibronection, and inhibited cell migration, suggesting that FGFR4 could contribute to tumour suppressive function via enhanced cell adhesion to extracellular matrix.65 Consistently, dominant‐negative FGFR‐4 and inhibitors of FGFR signalling inhibited matrix adhesion induced by N‐CAM (neural cell‐adhesion molecule) in pancreatic cancer. This evidence concerns the gene FGFR4 and familial pancreatic carcinoma.