One study reported that FGF‐10 can participate in transmitting mesenchyme signalling to the epithelium and involved in pancreas development.60 Stimulation of pancreatic cancer cells with FGF‐1, FGF‐2, FGF‐7 and FGF‐10 resulted in changes in the expression of key genes such as SOX‐9 (SRY‐related HMG‐box gene 9), HNF3β (hepatocyte nuclear factor 3‐beta), GATA‐4, GATA‐6 and HES1 (hairy and enhancer of split‐1).61 This study suggests that these growth factors might be involved in pancreatic cancer development. This evidence concerns the gene HES1 and pancreatic neoplasm.