FGFR2 and familial pancreatic carcinoma: In line with the role of FGFR2 in PDAC, overexpression of FGFR2 IIIc promoted cell proliferation in vitro and enhanced tumour growth and live metastases in vivo via upregulation of p‐ERK (phosphorylated extracellular signal‐regulated kinase) in PDAC.93 One study showed that targeting the CYP2B1/cyclophosphamide suicide system to FGFRs led to tumour suppressive response and an increased survival rate in pancreatic cancer.94