Overexpression of FGF‐5 promoted the cell growth and increased MAPK activity in pancreatic cancer.55 Expression of FGFR‐1 IIIc variant mediated FGF‐5‐induced mitogenic responsiveness through the MAPK pathway in pancreatic ductal cells, indicating that FGF‐5 in conjunction with FGFR‐1 IIIc could contribute to pancreatic cancer pathobiology.56, 57. This evidence concerns the gene FGF5 and pancreatic neoplasm.