Hypoxia, a common characteristic of solid tumours, has been reported to activate migration, invasion and VM formation in several tumour models including melanoma,23 oral squamous cell carcinoma24 and glioma.25 Here, we found that hypoxia accelerated VM formation of SACC and VEGFA was a critical downstream molecule that mediated the hypoxia‐controlled SACC VM in vitro. This evidence concerns the gene VEGFA and central nervous system cancer.